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Editorial Review: Atherosclerosis is a systemic disease that contributes to the death of 500,000 Americans by myocadial infarction and 150,000 Americans by stroke each year. In addition, peripheral arterial disease affects over 7 million Americans, two thirds of whom are undiagnosed. The modification of medical and lifestyle risk factors (e.g. diet, exercise, hypertension, smoking, and diabetes) and the daily administration of aspirin have been shown to save lives. However, aspirin is a relatively weak antiplatelet agent in that it interferes with one of the less significant intracellular processes that cause platelets to bind together. In this video, Drs. Hirsch, Raps, and Topol explore the role of new antiplatelet therapies in myocardial infarction, stroke, and peripheral arterial disease. Insights into the intracellular processes that take place in vascular disease and practical tips on patient management are illustrated through detailed visual patient case studies.
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